Assisted Reproductive Technology – Epigenetic Workshop

September 12, 2018

Le Westin
270 Saint-Antoine St W
Montreal, QC H2Y 0A3

Please join us to this RQR-CFAS joint workshop on Epigenetics taking place on September 12th at Le Westin. Note that this is a free event but space is limited: you must register to attend.

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Summary

This workshop is at the interface between the basic research on the transmission of phenotypic attributes to infant (F1) through epigenetic mechanisms and the Assisted Reproduction Technologies (ART). The goal is to identify and explain the potential factors involved in ART that may increase the effect of the environment (pre-conceptional, and during the IVF procedures) in the programming of future babies.  The use of animal models may improve the mechanistic understanding of the process since tissues are not always available in human for obvious ethical considerations.

Learning Objectives

  • To realize the role and impact of the early gamete’s and embryo’s environment on the future phenotype ( health of the IVF babies )
  • To create an awareness of which methods or procedures are the most problematic in ART.

Résumé

Cet atelier est à l’interface entre la recherche fondamentale sur la transmission des attributs phénotypiques au nourrisson (F1) à travers les mécanismes épigénétiques et les techniques de procréation médicalement assistée (PMA L’objectif est d’identifier et d’expliquer les facteurs potentiels impliqués dans la PMA qui peuvent augmenter l’effet de l’environnement (pré-conception, et pendant les procédures de FIV) dans la programmation des futurs bébés. L’utilisation de modèles animaux peut améliorer la compréhension mécanistique du processus puisque les tissus ne sont pas toujours disponibles chez l’humain pour des considérations éthiques évidentes.

Objectifs d’apprentissage

  • Réaliser le rôle et l’impact de l’environnement précoce des gamètes et des embryons sur le phénotype futur (santé des bébés FIV)
  • Faire prendre conscience des méthodes ou procédures les plus problématiques en ART.

Dr. Rinaudo is a Reproductive Endocrinologist based in San Francisco, California. He is currently Professor in residence at the University of California San Francisco. He received a MD, PhD at the University of Turin, Italy and then moved to the US. He completed a Residency in obstetrics and Gynecology at Yale University and a Fellowship in Reproductive Endocrinology at the University of Pennsylvania. The focus of his research is to understand how in vitro fertilization and in vitro culture during the pre-implantation period affect fetal and adult development. This has particular relevance in light of the widespread use of artificial reproductive techniques (ART). In fact, fetal adaptations in utero to adverse conditions can lead to specific diseases in the adult, including diabetes, high blood pressure and coronary heart disease. This phenomenon, termed the developmental origin of adult health and disease or the Barker hypothesis, has been extrapolated back to preimplantation development.

Summary

This presentation will highlight the changes that occur in mouse embryo following IVF. In particular we will describe the DNA methylation and chromatin changes present in the inner cell mass of male female mouse embryos generated spontaneously or after IVF

Learning Objectives

  1. Describe the DNA methylation changes that occur during development
  2. Understand how the environment can affect epigenetic changes during development
  3. Understand if epigenetic differences exist in male or female embryos